The High School of American Studies is located on the campus of Lehman College, a senior college in The City University of New York. The Lehman campus is located in the northwest Bronx, adjacent to the Jerome Park Reservoir and along an educational corridor that includes DeWitt Clinton High School, the Bronx High School of Science, P.S. 86 and the Walton High School campus.

The High School of American Studies has its own space in the College’s Reservoir Building, located on Goulden Avenue across from the main campus gate. While HSAS uses the Lehman campus for lunch, Physical Education, and some educational classes,  this facility serves as the school’s principal academic home.